Two Neuron Proteins Open a Route for Parkinson's Spread

Yale School of Medicine researchers identified mGluR4 and NPDC1 as neuronal surface proteins that help misfolded alpha-synuclein move through motor circuits. In mouse experiments, removing the proteins preserved dopamine-producing cells and reduced progression after exposure to the toxic protein. The findings are preclinical and do not establish a human treatment, but they narrow the search for interventions that could slow propagation rather than only manage symptoms.