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    "story_id": "mp-2026-07-18-010",
    "source_story_id": "tmp-story-sorla-tau-protection",
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    "headline": "A Sorting Protein Blunts Tau's Toxic Turn",
    "slug": "a-sorting-protein-blunts-tau-s-toxic-turn",
    "dek": "Extra SORLA reduced several processes tied to tau tangles and neurodegeneration in laboratory models.",
    "summary": "Extra SORLA reduced several processes tied to tau tangles and neurodegeneration in laboratory models.",
    "body_text": "Sanford Burnham Prebys researchers found that increasing SORLA reduced excessive tau phosphorylation and other harmful changes associated with tauopathies. The work identifies a protective pathway and a possible therapeutic direction. It does not show that raising SORLA is safe, feasible, or clinically effective in people with Alzheimer's disease.",
    "why_it_matters": "Extra SORLA reduced several processes tied to tau tangles and neurodegeneration in laboratory models.",
    "limitations": [
      "It does not show that raising SORLA is safe, feasible, or clinically effective in people with Alzheimer's disease."
    ],
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    "first_published_at": "2026-07-18T09:00:00.000-04:00",
    "modified_at": "2026-07-18T09:00:00.000-04:00",
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        "text": "Extra SORLA reduced several processes tied to tau tangles and neurodegeneration in laboratory models.",
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        "qualification": "It does not show that raising SORLA is safe, feasible, or clinically effective in people with Alzheimer's disease."
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    "tags": [
      "SORLA",
      "tau",
      "neurodegeneration"
    ],
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    "corrections": []
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    {
      "source_id": "source-2026-07-18-010",
      "title": "Sanford Burnham Prebys via Newswise: SORLA and tau toxicity",
      "publisher": "Sanford Burnham Prebys via Newswise",
      "url": "https://www.newswise.com/articles/protective-protein-reduces-tau-tangle-toxicity-linked-to-dementia",
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      "published_at": "2026-07-17T14:00:00.000-04:00",
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  "publisher": {
    "name": "The Machine Press",
    "url": "https://themachinepress.com",
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  "cite_this_report": {
    "title": "A Sorting Protein Blunts Tau's Toxic Turn",
    "publisher": "The Machine Press",
    "published_at": "2026-07-18T09:00:00.000-04:00",
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