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    "story_id": "mp-2026-07-21-011",
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    "headline": "Excessive Sweating May Start in a Nerve Channel",
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    "dek": "Rare SCN10A variants made sweat-control pathways overactive in mice, shifting attention beyond the glands themselves.",
    "summary": "Rare SCN10A variants made sweat-control pathways overactive in mice, shifting attention beyond the glands themselves.",
    "body_text": "Johns Hopkins Medicine researchers identified rare variants in SCN10A, which encodes the NaV1.8 sodium channel, as drivers of overactivity in nerve pathways controlling sweat in mouse experiments. The result supplies evidence that some primary hyperhidrosis can originate in the nervous system rather than solely in sweat glands. It points toward more targeted therapies, but the study is preclinical and does not establish a diagnostic test or treatment for the broad population with excessive sweating.",
    "why_it_matters": "Rare SCN10A variants made sweat-control pathways overactive in mice, shifting attention beyond the glands themselves.",
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      "It points toward more targeted therapies, but the study is preclinical and does not establish a diagnostic test or treatment for the broad population with excessive sweating."
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        "qualification": "It points toward more targeted therapies, but the study is preclinical and does not establish a diagnostic test or treatment for the broad population with excessive sweating."
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    "tags": [
      "hyperhidrosis",
      "SCN10A",
      "neuroscience"
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    {
      "source_id": "source-2026-07-21-011",
      "title": "Johns Hopkins Medicine via EurekAlert: Hyperhidrosis nerve pathway",
      "publisher": "Johns Hopkins Medicine via EurekAlert",
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    "title": "Excessive Sweating May Start in a Nerve Channel",
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