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    "headline": "Young Blood Stem Cells Showed the Wear of Age",
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    "dek": "Sickle cell disease pushed patient stem cells toward senescence, while two approved senolytics restored blood formation in models.",
    "summary": "Sickle cell disease pushed patient stem cells toward senescence, while two approved senolytics restored blood formation in models.",
    "body_text": "St. Jude researchers found aging-associated features in blood stem cells from patients ages 6 to 23 with sickle cell disease. In mouse models carrying patient cells, senolytic treatment reduced senescence markers and improved blood formation; dasatinib plus quercetin produced similar model results. The work may inform stem-cell collection for gene therapy, but it is preclinical and does not establish a treatment regimen for patients.",
    "why_it_matters": "Sickle cell disease pushed patient stem cells toward senescence, while two approved senolytics restored blood formation in models.",
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    "tags": [
      "sickle cell disease",
      "stem cells",
      "senescence"
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      "title": "St. Jude via Newswise: Sickle cell stem-cell aging",
      "publisher": "St. Jude Children's Research Hospital via Newswise",
      "url": "https://www.newswise.com/articles/premature-blood-stem-cell-aging-in-sickle-cell-disease-may-be-reversible",
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    "title": "Young Blood Stem Cells Showed the Wear of Age",
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