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    "story_id": "mp-2026-07-25-005",
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    "headline": "Inherited DNA May Shape a CAR-T Course",
    "slug": "inherited-dna-may-shape-a-car-t-course",
    "dek": "Whole-genome analysis linked germline variants to treatment activity and toxicity in aggressive lymphoma trials.",
    "summary": "Whole-genome analysis linked germline variants to treatment activity and toxicity in aggressive lymphoma trials.",
    "body_text": "Researchers analyzed whole genomes from more than 200 people treated with CAR-T cells in two aggressive-lymphoma trials. Variants near STXBP2 correlated with toxicity, ADAMTSL3 variants with protection, and PTPN22 variants with CAR-T expansion and activity. These are associations that need replication; they do not yet justify selecting or withholding treatment from an individual patient.",
    "why_it_matters": "Whole-genome analysis linked germline variants to treatment activity and toxicity in aggressive lymphoma trials.",
    "limitations": [
      "These are associations that need replication; they do not yet justify selecting or withholding treatment from an individual patient."
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    "first_published_at": "2026-07-25T09:00:00.000-04:00",
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        "text": "Whole-genome analysis linked germline variants to treatment activity and toxicity in aggressive lymphoma trials.",
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        "qualification": "These are associations that need replication; they do not yet justify selecting or withholding treatment from an individual patient."
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    "tags": [
      "CAR-T",
      "lymphoma",
      "genomics"
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  "sources": [
    {
      "source_id": "source-2026-07-25-005",
      "title": "Mass General Brigham via EurekAlert: Germline genetics and CAR-T",
      "publisher": "Mass General Brigham via EurekAlert",
      "url": "https://www.eurekalert.org/news-releases/1137211",
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    "name": "The Machine Press",
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    "description": "A daily newspaper for the age of artificial intelligence."
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    "title": "Inherited DNA May Shape a CAR-T Course",
    "publisher": "The Machine Press",
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