{
  "$schema": "https://themachinepress.com/schemas/story-v1.schema.json",
  "schema_version": "1.0.0",
  "document_type": "machine_press_story",
  "story": {
    "story_id": "mp-2026-07-25-007",
    "source_story_id": "tmp-story-muscle-repair-hgf-trisulfide",
    "edition_id": "mp-2026-07-25-morning-0016",
    "edition_url": "https://themachinepress.com/edition/2026-07-25",
    "position": 7,
    "story_type": "dispatch",
    "section": "research",
    "editorial_classification": "editorial",
    "headline": "A Sulfur Compound Shields a Muscle-Repair Signal",
    "slug": "a-sulfur-compound-shields-a-muscle-repair-signal",
    "dek": "Lipoic acid trisulfide limited nitration of hepatocyte growth factor in biochemical tests and a mouse disuse model.",
    "summary": "Lipoic acid trisulfide limited nitration of hepatocyte growth factor in biochemical tests and a mouse disuse model.",
    "body_text": "Kyushu University researchers found that lipoic acid trisulfide reduced chemical nitration of hepatocyte growth factor, a modification that weakens its ability to bind the c-Met receptor. At a high ratio in laboratory tests, protected HGF more than doubled receptor binding, and suspended mice showed less nitration after treatment. Aging studies, dosing, and safety work are still needed before the result can support a therapy.",
    "why_it_matters": "Lipoic acid trisulfide limited nitration of hepatocyte growth factor in biochemical tests and a mouse disuse model.",
    "limitations": [
      "At a high ratio in laboratory tests, protected HGF more than doubled receptor binding, and suspended mice showed less nitration after treatment."
    ],
    "importance": 8,
    "canonical_url": "https://themachinepress.com/story/mp-2026-07-25-007/a-sulfur-compound-shields-a-muscle-repair-signal",
    "json_url": "https://themachinepress.com/story/mp-2026-07-25-007.json",
    "first_published_at": "2026-07-25T09:00:00.000-04:00",
    "modified_at": "2026-07-25T09:00:00.000-04:00",
    "content_status": "new",
    "is_carryover": false,
    "carryover_reason": null,
    "key_claims": [
      {
        "claim_id": "claim-mp-2026-07-25-007-001",
        "text": "Lipoic acid trisulfide limited nitration of hepatocyte growth factor in biochemical tests and a mouse disuse model.",
        "source_ids": [
          "source-2026-07-25-007"
        ],
        "qualification": "At a high ratio in laboratory tests, protected HGF more than doubled receptor binding, and suspended mice showed less nitration after treatment."
      }
    ],
    "source_ids": [
      "source-2026-07-25-007"
    ],
    "tags": [
      "muscle repair",
      "hepatocyte growth factor",
      "aging"
    ],
    "image_url": null,
    "corrections": []
  },
  "sources": [
    {
      "source_id": "source-2026-07-25-007",
      "title": "Kyushu University via EurekAlert: HGF and lipoic acid trisulfide",
      "publisher": "Kyushu University via EurekAlert",
      "url": "https://www.eurekalert.org/news-releases/1136524",
      "canonical_url": "https://www.eurekalert.org/news-releases/1136524",
      "source_type": "official_announcement",
      "is_primary_source": true,
      "published_at": null,
      "accessed_at": "2026-07-25T08:26:47.000-04:00",
      "supports_claim_ids": [
        "claim-mp-2026-07-25-007-001"
      ]
    }
  ],
  "corrections": [],
  "publisher": {
    "name": "The Machine Press",
    "url": "https://themachinepress.com",
    "description": "A daily newspaper for the age of artificial intelligence."
  },
  "cite_this_report": {
    "title": "A Sulfur Compound Shields a Muscle-Repair Signal",
    "publisher": "The Machine Press",
    "published_at": "2026-07-25T09:00:00.000-04:00",
    "canonical_url": "https://themachinepress.com/story/mp-2026-07-25-007/a-sulfur-compound-shields-a-muscle-repair-signal"
  }
}
