{
  "$schema": "https://themachinepress.com/schemas/story-v1.schema.json",
  "schema_version": "1.0.0",
  "document_type": "machine_press_story",
  "story": {
    "story_id": "mp-2026-07-26-009",
    "source_story_id": "tmp-story-maternal-inflammation-rapamycin-mice",
    "edition_id": "mp-2026-07-26-morning-0017",
    "edition_url": "https://themachinepress.com/edition/2026-07-26",
    "position": 9,
    "story_type": "dispatch",
    "section": "research",
    "editorial_classification": "editorial",
    "headline": "One Rapamycin Dose Quieted an Overactive Mouse Brain",
    "slug": "one-rapamycin-dose-quieted-an-overactive-mouse-brain",
    "dek": "Adult offspring exposed to mild maternal inflammation showed sensory and behavioral abnormalities that largely eased after mTOR inhibition.",
    "summary": "Adult offspring exposed to mild maternal inflammation showed sensory and behavioral abnormalities that largely eased after mTOR inhibition.",
    "body_text": "In a mouse model, mild immune activation during pregnancy produced adult offspring with brain-circuit overactivity, altered sensory responses, repetitive behavior and greater seizure susceptibility. Researchers report that a single rapamycin dose rapidly improved most of the measured abnormalities by dampening mTOR signaling. The animals are described as showing autism-like traits, but a mouse rescue experiment is not evidence that rapamycin treats autism in people.",
    "why_it_matters": "Adult offspring exposed to mild maternal inflammation showed sensory and behavioral abnormalities that largely eased after mTOR inhibition.",
    "limitations": [
      "The animals are described as showing autism-like traits, but a mouse rescue experiment is not evidence that rapamycin treats autism in people."
    ],
    "importance": 8,
    "canonical_url": "https://themachinepress.com/story/mp-2026-07-26-009/one-rapamycin-dose-quieted-an-overactive-mouse-brain",
    "json_url": "https://themachinepress.com/story/mp-2026-07-26-009.json",
    "first_published_at": "2026-07-26T09:00:00.000-04:00",
    "modified_at": "2026-07-26T09:00:00.000-04:00",
    "content_status": "new",
    "is_carryover": false,
    "carryover_reason": null,
    "key_claims": [
      {
        "claim_id": "claim-mp-2026-07-26-009-001",
        "text": "Adult offspring exposed to mild maternal inflammation showed sensory and behavioral abnormalities that largely eased after mTOR inhibition.",
        "source_ids": [
          "source-2026-07-26-009"
        ],
        "qualification": "The animals are described as showing autism-like traits, but a mouse rescue experiment is not evidence that rapamycin treats autism in people."
      }
    ],
    "source_ids": [
      "source-2026-07-26-009"
    ],
    "tags": [
      "maternal inflammation",
      "mTOR",
      "rapamycin",
      "mouse model"
    ],
    "image_url": null,
    "corrections": []
  },
  "sources": [
    {
      "source_id": "source-2026-07-26-009",
      "title": "ScienceDaily: Maternal inflammation, mTOR and adult mouse behavior",
      "publisher": "ScienceDaily",
      "url": "https://www.sciencedaily.com/releases/2026/07/260724061436.htm",
      "canonical_url": "https://www.sciencedaily.com/releases/2026/07/260724061436.htm",
      "source_type": "secondary_reporting",
      "is_primary_source": false,
      "published_at": null,
      "accessed_at": "2026-07-26T08:35:02.238-04:00",
      "supports_claim_ids": [
        "claim-mp-2026-07-26-009-001"
      ]
    }
  ],
  "corrections": [],
  "publisher": {
    "name": "The Machine Press",
    "url": "https://themachinepress.com",
    "description": "A daily newspaper for the age of artificial intelligence."
  },
  "cite_this_report": {
    "title": "One Rapamycin Dose Quieted an Overactive Mouse Brain",
    "publisher": "The Machine Press",
    "published_at": "2026-07-26T09:00:00.000-04:00",
    "canonical_url": "https://themachinepress.com/story/mp-2026-07-26-009/one-rapamycin-dose-quieted-an-overactive-mouse-brain"
  }
}