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    "story_id": "mp-2026-07-30-006",
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    "headline": "The AI Editor Needed a Human Redesign",
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    "dek": "Structure-guided engineering raised the efficiency and precision of early AI-designed adenine base editors.",
    "summary": "Structure-guided engineering raised the efficiency and precision of early AI-designed adenine base editors.",
    "body_text": "A Sungkyunkwan University-led team used predicted protein structures to redesign early AI-derived adenine base editors, producing OpenABE 1.1 and 1.2. The researchers report 16- to 36-fold higher activity than the starting AI-designed editors, reduced nearby off-target editing and activity in nuclear and mitochondrial DNA; the work remains preclinical and does not establish a safe human gene therapy.",
    "why_it_matters": "Structure-guided engineering raised the efficiency and precision of early AI-designed adenine base editors.",
    "limitations": [
      "The researchers report 16- to 36-fold higher activity than the starting AI-designed editors, reduced nearby off-target editing and activity in nuclear and mitochondrial DNA; the work remains preclinical and does not establish a safe human gene therapy."
    ],
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    "first_published_at": "2026-07-30T09:00:00.000-04:00",
    "modified_at": "2026-07-30T09:00:00.000-04:00",
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        "text": "Structure-guided engineering raised the efficiency and precision of early AI-designed adenine base editors.",
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          "source-2026-07-30-006"
        ],
        "qualification": "The researchers report 16- to 36-fold higher activity than the starting AI-designed editors, reduced nearby off-target editing and activity in nuclear and mitochondrial DNA; the work remains preclinical and does not establish a safe human gene therapy."
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    "source_ids": [
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    "tags": [
      "OpenABE",
      "base editing",
      "protein engineering",
      "mitochondrial DNA"
    ],
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    "corrections": []
  },
  "sources": [
    {
      "source_id": "source-2026-07-30-006",
      "title": "Sungkyunkwan University via Newswise: Structure-guided improvement of AI-designed base editors",
      "publisher": "Sungkyunkwan University",
      "url": "https://www.newswise.com/articles/sungkyunkwan-university-research-team-successfully-advances-ai-designed-base-editors-paving-the-way-for-next-generation-gene-therapy",
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      "published_at": null,
      "accessed_at": "2026-07-30T08:30:57.270-04:00",
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  "publisher": {
    "name": "The Machine Press",
    "url": "https://themachinepress.com",
    "description": "A daily newspaper for the age of artificial intelligence."
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  "cite_this_report": {
    "title": "The AI Editor Needed a Human Redesign",
    "publisher": "The Machine Press",
    "published_at": "2026-07-30T09:00:00.000-04:00",
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