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    "headline": "Gut Bacteria Changed How Long a Cancer Drug Stayed in Circulation",
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    "dek": "Preclinical studies linked microbiome shifts to slower liver clearance and greater tumor delivery of nanoparticle chemotherapy.",
    "summary": "Preclinical studies linked microbiome shifts to slower liver clearance and greater tumor delivery of nanoparticle chemotherapy.",
    "body_text": "MD Anderson researchers found that metronidazole reshaped gut bacteria, bile acids and liver Kupffer-cell activity in preclinical models, roughly doubling the circulation time of a nanoparticle chemotherapy and increasing tumor accumulation. A fecal microbiota transfer reproduced key effects without antibiotics across models of colon, breast, melanoma and pancreatic cancers. The work is preclinical and does not establish a treatment regimen for people.",
    "why_it_matters": "Preclinical studies linked microbiome shifts to slower liver clearance and greater tumor delivery of nanoparticle chemotherapy.",
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      "MD Anderson researchers found that metronidazole reshaped gut bacteria, bile acids and liver Kupffer-cell activity in preclinical models, roughly doubling the circulation time of a nanoparticle chemotherapy and increasing tumor accumulation.",
      "The work is preclinical and does not establish a treatment regimen for people."
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      "title": "MD Anderson via Newswise: Microbiome and nanoparticle chemotherapy",
      "publisher": "University of Texas MD Anderson Cancer Center via Newswise",
      "url": "https://www.newswise.com/articles/reshaping-the-gut-microbiome-can-boost-chemotherapy-delivery-to-tumors",
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    "title": "Gut Bacteria Changed How Long a Cancer Drug Stayed in Circulation",
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