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    "story_id": "mp-2026-08-01-009",
    "source_story_id": "tmp-story-arginine-mhc1-translation",
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    "headline": "Low Arginine Jammed the Cell's Antigen-Display Machinery",
    "slug": "low-arginine-jammed-the-cell-s-antigen-display-machinery",
    "dek": "Cell and disease models show how scarcity of one amino acid can stall production of arginine-rich MHC-I proteins.",
    "summary": "Cell and disease models show how scarcity of one amino acid can stall production of arginine-rich MHC-I proteins.",
    "body_text": "Rockefeller University researchers report that low arginine stalls ribosomes while they translate arginine-rich MHC-I, or HLA, proteins, reducing the antigen display that helps immune cells spot threats. The team observed the mechanism in cell, cancer, influenza and SARS-CoV-2 models, and moderate supplementation rescued gene expression experimentally. The work is mechanistic and is not clinical advice to take arginine supplements.",
    "why_it_matters": "Cell and disease models show how scarcity of one amino acid can stall production of arginine-rich MHC-I proteins.",
    "limitations": [
      "The work is mechanistic and is not clinical advice to take arginine supplements."
    ],
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    "first_published_at": "2026-08-01T09:00:00.000-04:00",
    "modified_at": "2026-08-01T09:00:00.000-04:00",
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        "qualification": "The work is mechanistic and is not clinical advice to take arginine supplements."
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    "tags": [
      "arginine",
      "MHC-I",
      "ribosomes",
      "immune response"
    ],
    "image_url": null,
    "corrections": []
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      "source_id": "source-2026-08-01-009",
      "title": "Rockefeller University via Newswise: Arginine and MHC-I translation",
      "publisher": "Rockefeller University via Newswise",
      "url": "https://www.newswise.com/articles/the-amino-acid-arginine-helps-the-body-fight-tumors-and-viral-infections",
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      "accessed_at": "2026-08-01T08:36:00.000-04:00",
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    "name": "The Machine Press",
    "url": "https://themachinepress.com",
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  "cite_this_report": {
    "title": "Low Arginine Jammed the Cell's Antigen-Display Machinery",
    "publisher": "The Machine Press",
    "published_at": "2026-08-01T09:00:00.000-04:00",
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