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    "headline": "The Gut's Support Cells Changed Jobs in Three Weeks",
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    "dek": "Piglet stromal cells shifted the shape, growth and signaling of intestinal organoids across early development.",
    "summary": "Piglet stromal cells shifted the shape, growth and signaling of intestinal organoids across early development.",
    "body_text": "Researchers isolated jejunal mesenchymal stromal cells from newborn, seven-day and 21-day piglets and paired them with intestinal enteroids. Newborn cells supported larger, mostly cystic enteroids; seven-day cells favored more multi-budded structures and showed a transitional gene-expression profile; 21-day cells increased WNT and BMP antagonists. Brief calcium-channel inhibition in seven-day cells rapidly changed niche-factor expression. The work maps age-linked associations in piglet cells and co-cultures rather than proving a human developmental mechanism.",
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    "tags": [
      "intestinal development",
      "stromal cells",
      "organoids"
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      "title": "Frontiers in Cell and Developmental Biology: early piglet intestinal stromal cells",
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      "url": "https://doi.org/10.3389/fcell.2026.1847165",
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