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    "story_id": "mp-2026-08-05-005",
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    "headline": "Ketamine Broke the Threshold, Not the Neural Signal",
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    "dek": "Mouse cortical recordings retained strong drug-state ranking across five anesthetics once the decision boundary was recalibrated.",
    "summary": "Mouse cortical recordings retained strong drug-state ranking across five anesthetics once the decision boundary was recalibrated.",
    "body_text": "Researchers trained awake-versus-anesthetized decoders on mouse electrocorticography under five anesthetics and held out one drug at a time. Even for ketamine, band-power features ranked sessions with a reported AUROC of 0.980, but the fixed decision threshold pushed balanced accuracy toward chance. Anchoring the threshold to each subject's pre-induction baseline raised ketamine balanced accuracy from 0.50 to 0.85 and outperformed the tested domain-adaptation method. Because the ketamine sessions came from only three mice also represented under other drugs, the authors explicitly limit the claim to within-subject cross-drug transfer.",
    "why_it_matters": "Mouse cortical recordings retained strong drug-state ranking across five anesthetics once the decision boundary was recalibrated.",
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      "Because the ketamine sessions came from only three mice also represented under other drugs, the authors explicitly limit the claim to within-subject cross-drug transfer."
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    "first_published_at": "2026-08-05T09:00:00.000-04:00",
    "modified_at": "2026-08-05T09:00:00.000-04:00",
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        "text": "Mouse cortical recordings retained strong drug-state ranking across five anesthetics once the decision boundary was recalibrated.",
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        "qualification": "Because the ketamine sessions came from only three mice also represented under other drugs, the authors explicitly limit the claim to within-subject cross-drug transfer."
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    "tags": [
      "anesthesia",
      "ECoG",
      "calibration",
      "ketamine"
    ],
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  "sources": [
    {
      "source_id": "source-2026-08-05-005",
      "title": "arXiv preprint 2608.02646",
      "publisher": "arXiv",
      "url": "https://arxiv.org/abs/2608.02646",
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  "cite_this_report": {
    "title": "Ketamine Broke the Threshold, Not the Neural Signal",
    "publisher": "The Machine Press",
    "published_at": "2026-08-05T09:00:00.000-04:00",
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