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    "headline": "A Near-Perfect Cancer Score Lost Its Operating Point",
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    "dek": "Across nine cohorts, compact gene panels could discriminate well while locked sensitivity or specificity collapsed.",
    "summary": "Across nine cohorts, compact gene panels could discriminate well while locked sensitivity or specificity collapsed.",
    "body_text": "The REDE preprint audited differential-expression evidence across nine public microarray cohorts spanning pancreatic, breast and lung cancers. Exact gene-list confirmation was often limited, while large effects and pathways replicated more consistently. Some compact 19-gene panels retained ROC-AUC values near one on external data yet failed at the discovery cohort's fixed decision threshold, producing zero specificity or very low sensitivity. The authors frame reproducibility as a ladder from list membership through effect, pathway, discrimination and operating-point transfer; the analysis is retrospective and does not validate a clinical diagnostic.",
    "why_it_matters": "Across nine cohorts, compact gene panels could discriminate well while locked sensitivity or specificity collapsed.",
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      "The authors frame reproducibility as a ladder from list membership through effect, pathway, discrimination and operating-point transfer; the analysis is retrospective and does not validate a clinical diagnostic."
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    "tags": [
      "cancer",
      "gene expression",
      "reproducibility",
      "diagnostics"
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      "title": "arXiv preprint 2608.02796",
      "publisher": "arXiv",
      "url": "https://arxiv.org/abs/2608.02796",
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    "title": "A Near-Perfect Cancer Score Lost Its Operating Point",
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