{
  "$schema": "https://themachinepress.com/schemas/story-v1.schema.json",
  "schema_version": "1.0.0",
  "document_type": "machine_press_story",
  "story": {
    "story_id": "mp-2026-10-30-004",
    "source_story_id": "tmp-story-clingex-genomic-skills",
    "edition_id": "mp-2026-10-30-morning-0112",
    "edition_url": "https://themachinepress.com/edition/2026-10-30",
    "position": 4,
    "story_type": "dispatch",
    "section": "research",
    "editorial_classification": "editorial",
    "headline": "One Hundred Five Skills Enter the Genomics Workflow",
    "slug": "one-hundred-five-skills-enter-the-genomics-workflow",
    "dek": "On 223 held-out cases, ClinGeX reached 71.7 percent task-level concordance with expert reference classifications, versus 45.7 percent for the strongest comparator.",
    "summary": "On 223 held-out cases, ClinGeX reached 71.7 percent task-level concordance with expert reference classifications, versus 45.7 percent for the strongest comparator.",
    "body_text": "Clinical genomic interpretation requires guidelines, databases and executable analysis to stay aligned as evidence changes. ClinGeX retrieves and orchestrates 105 curated skills with explicit dependencies. On 223 temporally held-out cases, it achieved 71.7 percent macro-averaged task-level concordance with expert references, compared with 45.7 percent for the strongest comparator. In a counterbalanced study, 45 professionals assessed 135 cases under routine, DeepSeek-assisted and ClinGeX-assisted conditions; the ClinGeX condition raised raw concordance across three task families and reduced reported interpretation time. An exploratory month-long assessment gathered feedback from 11 professionals on 96 self-selected episodes. These are promising assistance results, not prospective evidence of clinical safety or autonomous diagnosis.",
    "why_it_matters": "On 223 held-out cases, ClinGeX reached 71.7 percent task-level concordance with expert reference classifications, versus 45.7 percent for the strongest comparator.",
    "limitations": [
      "These are promising assistance results, not prospective evidence of clinical safety or autonomous diagnosis."
    ],
    "importance": 9,
    "canonical_url": "https://themachinepress.com/story/mp-2026-10-30-004/one-hundred-five-skills-enter-the-genomics-workflow",
    "json_url": "https://themachinepress.com/story/mp-2026-10-30-004.json",
    "first_published_at": "2026-10-30T09:00:00.000-04:00",
    "modified_at": "2026-10-30T09:00:00.000-04:00",
    "content_status": "new",
    "is_carryover": false,
    "carryover_reason": null,
    "key_claims": [
      {
        "claim_id": "claim-mp-2026-10-30-004-001",
        "text": "On 223 held-out cases, ClinGeX reached 71.7 percent task-level concordance with expert reference classifications, versus 45.7 percent for the strongest comparator.",
        "source_ids": [
          "source-2026-10-30-004"
        ],
        "qualification": "These are promising assistance results, not prospective evidence of clinical safety or autonomous diagnosis."
      }
    ],
    "source_ids": [
      "source-2026-10-30-004"
    ],
    "tags": [
      "clinical genomics",
      "AI agents",
      "healthcare",
      "decision support"
    ],
    "image_url": null,
    "corrections": []
  },
  "sources": [
    {
      "source_id": "source-2026-10-30-004",
      "title": "arXiv preprint 2610.40556, original v1",
      "publisher": "arXiv",
      "url": "https://arxiv.org/abs/2610.40556v1",
      "canonical_url": "https://arxiv.org/abs/2610.40556v1",
      "source_type": "primary_research",
      "is_primary_source": true,
      "published_at": "2026-10-28T20:00:00.000-04:00",
      "accessed_at": "2026-10-30T08:14:40.422-04:00",
      "supports_claim_ids": [
        "claim-mp-2026-10-30-004-001"
      ]
    }
  ],
  "corrections": [],
  "publisher": {
    "name": "The Machine Press",
    "url": "https://themachinepress.com",
    "description": "A daily newspaper for the age of artificial intelligence."
  },
  "cite_this_report": {
    "title": "One Hundred Five Skills Enter the Genomics Workflow",
    "publisher": "The Machine Press",
    "published_at": "2026-10-30T09:00:00.000-04:00",
    "canonical_url": "https://themachinepress.com/story/mp-2026-10-30-004/one-hundred-five-skills-enter-the-genomics-workflow"
  }
}