research
A Brain Transporter Revealed Its Shape—and Its First Blockers
The first high-resolution NBCn2 structure guided compounds that reduced activity in tissue studies.
Summary
The first high-resolution NBCn2 structure guided compounds that reduced activity in tissue studies.
Mount Sinai researchers resolved the high-resolution structure of NBCn2, a brain protein that regulates acid-base balance and has genetic links to epilepsy and other neurological conditions. The team also developed compounds that inhibited the transporter and reduced brain activity in tissue experiments. The work establishes a molecular tool and potential target, not a tested therapy.
Why it matters
The first high-resolution NBCn2 structure guided compounds that reduced activity in tissue studies.
Limits and context
- The work establishes a molecular tool and potential target, not a tested therapy.
Key claims
The first high-resolution NBCn2 structure guided compounds that reduced activity in tissue studies.
Qualification: The work establishes a molecular tool and potential target, not a tested therapy.
Evidence: source-2026-07-23-010
Sources
- Mount Sinai via Newswise: NBCn2 structure and inhibitorsMount Sinai Health System via Newswise · secondary reporting
Corrections
No corrections have been recorded for this story.