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A Sulfur Compound Shields a Muscle-Repair Signal
Lipoic acid trisulfide limited nitration of hepatocyte growth factor in biochemical tests and a mouse disuse model.
Summary
Lipoic acid trisulfide limited nitration of hepatocyte growth factor in biochemical tests and a mouse disuse model.
Kyushu University researchers found that lipoic acid trisulfide reduced chemical nitration of hepatocyte growth factor, a modification that weakens its ability to bind the c-Met receptor. At a high ratio in laboratory tests, protected HGF more than doubled receptor binding, and suspended mice showed less nitration after treatment. Aging studies, dosing, and safety work are still needed before the result can support a therapy.
Why it matters
Lipoic acid trisulfide limited nitration of hepatocyte growth factor in biochemical tests and a mouse disuse model.
Limits and context
- At a high ratio in laboratory tests, protected HGF more than doubled receptor binding, and suspended mice showed less nitration after treatment.
Key claims
Lipoic acid trisulfide limited nitration of hepatocyte growth factor in biochemical tests and a mouse disuse model.
Qualification: At a high ratio in laboratory tests, protected HGF more than doubled receptor binding, and suspended mice showed less nitration after treatment.
Evidence: source-2026-07-25-007
Sources
- Kyushu University via EurekAlert: HGF and lipoic acid trisulfideKyushu University via EurekAlert · official announcement
Corrections
No corrections have been recorded for this story.