weird machine
An RNA Degrader Stayed on the Mitochondrion
Engineered MOM-ENDOG suppressed four RNA viruses in cells while avoiding the nucleus in the reported experiments.
Summary
Engineered MOM-ENDOG suppressed four RNA viruses in cells while avoiding the nucleus in the reported experiments.
National Taiwan University researchers anchored an RNA-cutting enzyme to the mitochondrial surface and delivered modified mRNA encoding it. The construct reduced VSV, influenza, dengue and Zika propagation in experimental systems without the nuclear DNA damage seen when ENDOG moved into the nucleus; clinical safety is untested.
Why it matters
Engineered MOM-ENDOG suppressed four RNA viruses in cells while avoiding the nucleus in the reported experiments.
Limits and context
No additional limitation was separately recorded.
Key claims
Engineered MOM-ENDOG suppressed four RNA viruses in cells while avoiding the nucleus in the reported experiments.
Evidence: source-2026-08-02-021
Sources
- Nature Communications: mitochondrial-surface viral RNA degraderNature Communications · secondary reporting
Corrections
No corrections have been recorded for this story.