research
The Arrhythmia Circuit Hid Between the Heart's Surfaces
Patient-specific digital twins linked through-wall fibrosis patterns to endocardial and epicardial electrical separation.
Summary
Patient-specific digital twins linked through-wall fibrosis patterns to endocardial and epicardial electrical separation.
MRI-derived bi-atrial digital twins from 21 people with persistent atrial fibrillation produced 91 reentry-sustaining regions for comparison with 73 controls. Reentry regions showed substantially greater voltage and activation-time differences between inner and outer atrial surfaces, while fibrosis percentage and through-wall dissimilarity independently tracked reentry. The work is mechanistic simulation evidence, not a tested ablation protocol.
Why it matters
Patient-specific digital twins linked through-wall fibrosis patterns to endocardial and epicardial electrical separation.
Limits and context
- The work is mechanistic simulation evidence, not a tested ablation protocol.
Key claims
Patient-specific digital twins linked through-wall fibrosis patterns to endocardial and epicardial electrical separation.
Qualification: The work is mechanistic simulation evidence, not a tested ablation protocol.
Evidence: source-2026-08-03-012
Sources
- The Journal of Physiology: transmural fibrosis in persistent atrial fibrillationWiley · secondary reporting
Corrections
No corrections have been recorded for this story.