research
Diabetes Rewired Signals Across Four Reproductive Organs
A macaque single-cell atlas linked type 1 diabetes to inflammatory and hormone-response changes across the reproductive axis.
Summary
A macaque single-cell atlas linked type 1 diabetes to inflammatory and hormone-response changes across the reproductive axis.
Single-cell profiles of hypothalamus, pituitary, ovary and uterus found broad TNF-pathway activation, tissue-specific MIF signaling and reduced follicle-stimulating-hormone receptor expression in granulosa-cell differentiation. The nonhuman-primate atlas is mechanistic and preclinical.
Why it matters
A macaque single-cell atlas linked type 1 diabetes to inflammatory and hormone-response changes across the reproductive axis.
Limits and context
- The nonhuman-primate atlas is mechanistic and preclinical.
Key claims
A macaque single-cell atlas linked type 1 diabetes to inflammatory and hormone-response changes across the reproductive axis.
Qualification: The nonhuman-primate atlas is mechanistic and preclinical.
Evidence: source-2026-08-04-017
Sources
- Cell Discovery: reproductive endocrine single-cell atlas in diabetic macaquesSpringer Nature · secondary reporting
Corrections
No corrections have been recorded for this story.