research
One Hundred Five Skills Enter the Genomics Workflow
On 223 held-out cases, ClinGeX reached 71.7 percent task-level concordance with expert reference classifications, versus 45.7 percent for the strongest comparator.
Summary
On 223 held-out cases, ClinGeX reached 71.7 percent task-level concordance with expert reference classifications, versus 45.7 percent for the strongest comparator.
Clinical genomic interpretation requires guidelines, databases and executable analysis to stay aligned as evidence changes. ClinGeX retrieves and orchestrates 105 curated skills with explicit dependencies. On 223 temporally held-out cases, it achieved 71.7 percent macro-averaged task-level concordance with expert references, compared with 45.7 percent for the strongest comparator. In a counterbalanced study, 45 professionals assessed 135 cases under routine, DeepSeek-assisted and ClinGeX-assisted conditions; the ClinGeX condition raised raw concordance across three task families and reduced reported interpretation time. An exploratory month-long assessment gathered feedback from 11 professionals on 96 self-selected episodes. These are promising assistance results, not prospective evidence of clinical safety or autonomous diagnosis.
Why it matters
On 223 held-out cases, ClinGeX reached 71.7 percent task-level concordance with expert reference classifications, versus 45.7 percent for the strongest comparator.
Limits and context
- These are promising assistance results, not prospective evidence of clinical safety or autonomous diagnosis.
Key claims
On 223 held-out cases, ClinGeX reached 71.7 percent task-level concordance with expert reference classifications, versus 45.7 percent for the strongest comparator.
Qualification: These are promising assistance results, not prospective evidence of clinical safety or autonomous diagnosis.
Evidence: source-2026-10-30-004
Sources
- arXiv preprint 2610.40556, original v1arXiv · primary research
Corrections
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