research
The Abdomen Added a Small Clue to Brain Age
CT-derived fat and liver markers explained a modest extra share of MRI brain-age variation in women.
Summary
CT-derived fat and liver markers explained a modest extra share of MRI brain-age variation in women.
A retrospective screening cohort included 1,280 women who had both abdominal CT and brain MRI. After adjustment for age, body-mass index, blood markers and health behaviors, a higher abdominal fat ratio was associated with an older MRI-derived brain-age gap, while a higher liver-to-spleen attenuation ratio was associated with a younger gap. Both measures retained independent associations and added modest explanatory value beyond clinical covariates. The study is cross-sectional and associative; it does not show that changing either CT marker will alter brain aging.
Why it matters
CT-derived fat and liver markers explained a modest extra share of MRI brain-age variation in women.
Limits and context
- The study is cross-sectional and associative; it does not show that changing either CT marker will alter brain aging.
Key claims
CT-derived fat and liver markers explained a modest extra share of MRI brain-age variation in women.
Qualification: The study is cross-sectional and associative; it does not show that changing either CT marker will alter brain aging.
Evidence: source-2026-08-04-014
Sources
- Frontiers in Aging Neuroscience: abdominal CT phenotypes and brain ageFrontiers · secondary reporting
Corrections
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