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Ketamine Broke the Threshold, Not the Neural Signal
Mouse cortical recordings retained strong drug-state ranking across five anesthetics once the decision boundary was recalibrated.
Summary
Mouse cortical recordings retained strong drug-state ranking across five anesthetics once the decision boundary was recalibrated.
Researchers trained awake-versus-anesthetized decoders on mouse electrocorticography under five anesthetics and held out one drug at a time. Even for ketamine, band-power features ranked sessions with a reported AUROC of 0.980, but the fixed decision threshold pushed balanced accuracy toward chance. Anchoring the threshold to each subject's pre-induction baseline raised ketamine balanced accuracy from 0.50 to 0.85 and outperformed the tested domain-adaptation method. Because the ketamine sessions came from only three mice also represented under other drugs, the authors explicitly limit the claim to within-subject cross-drug transfer.
Why it matters
Mouse cortical recordings retained strong drug-state ranking across five anesthetics once the decision boundary was recalibrated.
Limits and context
- Because the ketamine sessions came from only three mice also represented under other drugs, the authors explicitly limit the claim to within-subject cross-drug transfer.
Key claims
Mouse cortical recordings retained strong drug-state ranking across five anesthetics once the decision boundary was recalibrated.
Qualification: Because the ketamine sessions came from only three mice also represented under other drugs, the authors explicitly limit the claim to within-subject cross-drug transfer.
Evidence: source-2026-08-05-005
Sources
- arXiv preprint 2608.02646arXiv · primary research
Corrections
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